Prediction of alternatively spliced exons using Support Vector Machines

Accurate identification of alternatively spliced exons using support vector machine

MOTIVATION Alternative splicing is a major component of the regulatory action on mammalian transcriptomes. It is estimated that over half of all human genes have more than one splice variant. Previous studies have shown that alternatively spliced exons possess several features that distinguish them from constitutively spliced ones. Recently, we have demonstrated that such features can be used t...

Prediction and statistical analysis of alternatively spliced exons.

Recognition of Unknown Conserved Alternatively Spliced Exons

The split structure of most mammalian protein-coding genes allows for the potential to produce multiple different mRNA and protein isoforms from a single gene locus through the process of alternative splicing (AS). We propose a computational approach called UNCOVER based on a pair hidden Markov model to discover conserved coding exonic sequences subject to AS that have so far gone undetected. A...

Alu-containing exons are alternatively spliced.

Alu repetitive elements are found in approximately 1.4 million copies in the human genome, comprising more than one-tenth of it. Numerous studies describe exonizations of Alu elements, that is, splicing-mediated insertions of parts of Alu sequences into mature mRNAs. To study the connection between the exonization of Alu elements and alternative splicing, we used a database of ESTs and cDNAs al...

STAGE-DISCHARGE MODELING USING SUPPORT VECTOR MACHINES

Establishment of rating curves are often required by the hydrologists for flow estimates in the streams, rivers etc. Measurement of discharge in a river is a time-consuming, expensive, and difficult process and the conventional approach of regression analysis of stage-discharge relation does not provide encouraging results especially during the floods. P